Nurse Practitioner · Salary Comparison · 2026
Nurse Practitioner Salary: Minneapolis, MN vs San Francisco, CA
Side-by-side comparison of salary, taxes, cost of living, and take-home pay for Nurse Practitioners in Minneapolis, MN and San Francisco, CA, based on BLS OEWS 2026 data.
1Which City Pays More After Tax?
Higher Gross Salary
✓ San Francisco, CA
$112,000 vs $155,000
Better Purchasing Power
✓ Minneapolis, MN
$100,901 vs $83,333
Best Take-Home (COL-Adj)
✓ Minneapolis, MN
$86,893 vs $69,839
2
Detailed Comparison
| Metric | Minneapolis, MN | San Francisco, CA | Diff |
|---|---|---|---|
| Median Annual Salary | $112,000 | $155,000▲ | -$43,000 |
| 25th Percentile | $86,000 | $120,000▲ | -$34,000 |
| 75th Percentile | $143,000 | $198,000▲ | -$55,000 |
| 90th Percentile | $174,000 | $240,000▲ | -$66,000 |
| Cost of Living Index | 111 | 186 | -75 |
| State Income Tax | 6.8%▲ | 9.3% | -2.500000000000001% |
| COL-Adjusted Median | $100,901▲ | $83,333 | +$17,568 |
| Est. Annual Take-Home | $96,451 | $129,901▲ | -$33,450 |
| COL-Adj. Take-Home | $86,893▲ | $69,839 | +$17,054 |
| Total Employment | 7,000 | 5,000 | +2,000 |
▲ = Higher value wins for this metric. Diff = Minneapolis, MN minus San Francisco, CA.
3Summary Analysis
On paper, San Francisco, CA pays $43,000 more (median: $112,000 vs $155,000). However, after adjusting for cost of living (index 111 vs 186), Minneapolis, MN provides better purchasing power ($100,901 vs $83,333 equivalent). Minneapolis, MN has the lower state tax rate (6.8% vs 9.3%).
Data: U.S. Bureau of Labor Statistics OEWS · 2026 · Cost-of-living indices from composite metro area data. Take-home estimates approximate only — consult a tax professional for accurate figures.