Nurse Practitioner Salary: Indianapolis, IN vs San Francisco, CA
Side-by-side comparison of wages and local price levels for Nurse Practitioners in Indianapolis, IN and San Francisco, CA, based on BLS OEWS May 2025 wage data and BEA regional price parities for 2024.
1Which City Pays More?
Detailed Comparison
| Metric | Indianapolis, IN | San Francisco, CA | Diff |
|---|---|---|---|
| Median Annual Salary | $130,460 | $219,080▲ | -$88,620 |
| 25th Percentile | $122,720 | $176,490▲ | -$53,770 |
| 75th Percentile | $136,130 | $241,910▲ | -$105,780 |
| 90th Percentile | $152,090 | $273,960▲ | -$121,870 |
| Price Level (BEA 2024, US = 100) | 95.7 | 115.6 | -19.9 |
| Median at National-Average Prices | $136,328 | $189,494▲ | -$53,166 |
| Total Employment | 2,530 | 3,110 | -580 |
3Summary Analysis
On paper, San Francisco, CA pays $88,620 more (median: $130,460 vs $219,080). BEA's regional price parity is 95.7 in Indianapolis, IN and 115.6 in San Francisco, CA (United States = 100). At national-average prices the medians are $136,328 and $189,494, so San Francisco, CA comes out ahead once local prices are counted.
5Reading This Comparison
The $88,620 gap between the two medians is a gap in dollars, not in what those dollars buy. Dividing each median by its area's regional price parity restates it at national-average prices: $136,328 for Indianapolis and $189,494 for San Francisco, a difference of $53,166.
The price levels come from the U.S. Bureau of Economic Analysis, which describes them this way: “Regional price parities (RPPs) measure the differences in price levels across states and metropolitan areas for a given year and are expressed as a percentage of the overall national price level.” The figures used here are the all-items index for each whole metropolitan area (Indianapolis-Carmel-Greenwood, IN; San Francisco-Oakland-Fremont, CA) and cover prices only, not taxes.
BLS estimates 2,530 Nurse Practitioner jobs in the Indianapolis area and 3,110 in the San Francisco area. For broader context, see our Indiana overview and the full Nurse Practitioner city ranking.
Frequently Asked Questions
Is Nurse Practitioner salary higher in Indianapolis, IN or San Francisco, CA?
San Francisco, CA has the higher median wage for Nurse Practitioners ($219,080 per year, against $130,460 in Indianapolis, IN; BLS OEWS May 2025). Restated at national-average prices using BEA regional price parities, the medians are $136,328 in Indianapolis, IN and $189,494 in San Francisco, CA.
How do prices compare between Indianapolis, IN and San Francisco, CA?
The U.S. Bureau of Economic Analysis puts the 2024 regional price parity at 95.7 for the Indianapolis-Carmel-Greenwood, IN metropolitan area and 115.6 for the San Francisco-Oakland-Fremont, CA metropolitan area, where the United States is 100. That is 4.3% below the national level for Indianapolis, IN and 15.6% above the national level for San Francisco, CA.
Which city pays Nurse Practitioners more once local prices are counted?
San Francisco, CA: at national-average prices its median Nurse Practitioner wage is $189,494, against $136,328 for Indianapolis, IN. The adjustment divides each median by the area's BEA regional price parity and covers prices only, not taxes.