Nurse Practitioner · Salary Comparison · 2026
Nurse Practitioner Salary: Indianapolis, IN vs San Francisco, CA
Side-by-side comparison of salary, taxes, cost of living, and take-home pay for Nurse Practitioners in Indianapolis, IN and San Francisco, CA, based on BLS OEWS 2026 data.
1Which City Pays More After Tax?
Higher Gross Salary
✓ San Francisco, CA
$95,000 vs $155,000
Better Purchasing Power
✓ Indianapolis, IN
$105,556 vs $83,333
Best Take-Home (COL-Adj)
✓ Indianapolis, IN
$94,461 vs $69,839
2
Detailed Comparison
| Metric | Indianapolis, IN | San Francisco, CA | Diff |
|---|---|---|---|
| Median Annual Salary | $95,000 | $155,000▲ | -$60,000 |
| 25th Percentile | $73,000 | $120,000▲ | -$47,000 |
| 75th Percentile | $122,000 | $198,000▲ | -$76,000 |
| 90th Percentile | $148,000 | $240,000▲ | -$92,000 |
| Cost of Living Index | 90 | 186 | -96 |
| State Income Tax | 3.15%▲ | 9.3% | -6.15% |
| COL-Adjusted Median | $105,556▲ | $83,333 | +$22,223 |
| Est. Annual Take-Home | $85,015 | $129,901▲ | -$44,886 |
| COL-Adj. Take-Home | $94,461▲ | $69,839 | +$24,622 |
| Total Employment | 5,000 | 5,000 | — |
▲ = Higher value wins for this metric. Diff = Indianapolis, IN minus San Francisco, CA.
3Summary Analysis
On paper, San Francisco, CA pays $60,000 more (median: $95,000 vs $155,000). However, after adjusting for cost of living (index 90 vs 186), Indianapolis, IN provides better purchasing power ($105,556 vs $83,333 equivalent). Indianapolis, IN has the lower state tax rate (3.15% vs 9.3%).
Data: U.S. Bureau of Labor Statistics OEWS · 2026 · Cost-of-living indices from composite metro area data. Take-home estimates approximate only — consult a tax professional for accurate figures.