SalariesByCity
Medical Assistant · Salary Comparison · 2026

Medical Assistant Salary: San Francisco, CA vs Denver, CO

Side-by-side comparison of salary, taxes, cost of living, and take-home pay for Medical Assistants in San Francisco, CA and Denver, CO, based on BLS OEWS 2026 data.

1Which City Pays More After Tax?

Higher Gross Salary
San Francisco, CA
$53,000 vs $41,000
Better Purchasing Power
Denver, CO
$28,495 vs $32,031
Best Take-Home (COL-Adj)
Denver, CO
$23,881 vs $28,295
2

Detailed Comparison

MetricSan Francisco, CADenver, CODiff
Median Annual Salary$53,000$41,000+$12,000
25th Percentile$40,810$31,570+$9,240
75th Percentile$67,840$52,480+$15,360
90th Percentile$84,800$65,600+$19,200
Cost of Living Index186128+58
State Income Tax9.3%4.4%+4.9%
COL-Adjusted Median$28,495$32,031-$3,536
Est. Annual Take-Home$44,418$36,217+$8,201
COL-Adj. Take-Home$23,881$28,295-$4,414
Total Employment130,00070,000+60,000
▲ = Higher value wins for this metric. Diff = San Francisco, CA minus Denver, CO.

3Summary Analysis

On paper, San Francisco, CA pays $12,000 more (median: $53,000 vs $41,000). However, after adjusting for cost of living (index 186 vs 128), Denver, CO provides better purchasing power ($28,495 vs $32,031 equivalent). Denver, CO has the lower state tax rate (4.4% vs 9.3%).

Data: U.S. Bureau of Labor Statistics OEWS · 2026 · Cost-of-living indices from composite metro area data. Take-home estimates approximate only — consult a tax professional for accurate figures.