Registered Nurse · Salary Comparison · 2026
Registered Nurse Salary: Minneapolis, MN vs San Francisco, CA
Side-by-side comparison of salary, taxes, cost of living, and take-home pay for Registered Nurses in Minneapolis, MN and San Francisco, CA, based on BLS OEWS 2026 data.
1Which City Pays More After Tax?
Higher Gross Salary
✓ San Francisco, CA
$80,000 vs $130,000
Better Purchasing Power
✓ Minneapolis, MN
$72,072 vs $69,892
Best Take-Home (COL-Adj)
✓ Minneapolis, MN
$62,066 vs $58,575
2
Detailed Comparison
| Metric | Minneapolis, MN | San Francisco, CA | Diff |
|---|---|---|---|
| Median Annual Salary | $80,000 | $130,000▲ | -$50,000 |
| 25th Percentile | $62,000 | $100,000▲ | -$38,000 |
| 75th Percentile | $102,000 | $165,000▲ | -$63,000 |
| 90th Percentile | $124,000 | $200,000▲ | -$76,000 |
| Cost of Living Index | 111 | 186 | -75 |
| State Income Tax | 6.8%▲ | 9.3% | -2.500000000000001% |
| COL-Adjusted Median | $72,072▲ | $69,892 | +$2,180 |
| Est. Annual Take-Home | $68,893 | $108,949▲ | -$40,056 |
| COL-Adj. Take-Home | $62,066▲ | $58,575 | +$3,491 |
| Total Employment | 30,000 | 28,000 | +2,000 |
▲ = Higher value wins for this metric. Diff = Minneapolis, MN minus San Francisco, CA.
3Summary Analysis
On paper, San Francisco, CA pays $50,000 more (median: $80,000 vs $130,000). However, after adjusting for cost of living (index 111 vs 186), Minneapolis, MN provides better purchasing power ($72,072 vs $69,892 equivalent). Minneapolis, MN has the lower state tax rate (6.8% vs 9.3%).
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Data: U.S. Bureau of Labor Statistics OEWS · 2026 · Cost-of-living indices from composite metro area data. Take-home estimates approximate only — consult a tax professional for accurate figures.