Registered Nurse · Salary Comparison · 2026
Registered Nurse Salary: Indianapolis, IN vs San Francisco, CA
Side-by-side comparison of salary, taxes, cost of living, and take-home pay for Registered Nurses in Indianapolis, IN and San Francisco, CA, based on BLS OEWS 2026 data.
1Which City Pays More After Tax?
Higher Gross Salary
✓ San Francisco, CA
$65,000 vs $130,000
Better Purchasing Power
✓ Indianapolis, IN
$72,222 vs $69,892
Best Take-Home (COL-Adj)
✓ Indianapolis, IN
$64,631 vs $58,575
2
Detailed Comparison
| Metric | Indianapolis, IN | San Francisco, CA | Diff |
|---|---|---|---|
| Median Annual Salary | $65,000 | $130,000▲ | -$65,000 |
| 25th Percentile | $50,000 | $100,000▲ | -$50,000 |
| 75th Percentile | $83,000 | $165,000▲ | -$82,000 |
| 90th Percentile | $102,000 | $200,000▲ | -$98,000 |
| Cost of Living Index | 90 | 186 | -96 |
| State Income Tax | 3.15%▲ | 9.3% | -6.15% |
| COL-Adjusted Median | $72,222▲ | $69,892 | +$2,330 |
| Est. Annual Take-Home | $58,168 | $108,949▲ | -$50,781 |
| COL-Adj. Take-Home | $64,631▲ | $58,575 | +$6,056 |
| Total Employment | 25,000 | 28,000 | -3,000 |
▲ = Higher value wins for this metric. Diff = Indianapolis, IN minus San Francisco, CA.
3Summary Analysis
On paper, San Francisco, CA pays $65,000 more (median: $65,000 vs $130,000). However, after adjusting for cost of living (index 90 vs 186), Indianapolis, IN provides better purchasing power ($72,222 vs $69,892 equivalent). Indianapolis, IN has the lower state tax rate (3.15% vs 9.3%).
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Data: U.S. Bureau of Labor Statistics OEWS · 2026 · Cost-of-living indices from composite metro area data. Take-home estimates approximate only — consult a tax professional for accurate figures.