SalariesByCity
Pharmacist · Salary Comparison · 2026

Pharmacist Salary: San Diego, CA vs San Francisco, CA

Side-by-side comparison of salary, taxes, cost of living, and take-home pay for Pharmacists in San Diego, CA and San Francisco, CA, based on BLS OEWS 2026 data.

1Which City Pays More After Tax?

Higher Gross Salary
San Francisco, CA
$104,000 vs $126,000
Better Purchasing Power
San Diego, CA
$68,421 vs $67,742
Best Take-Home (COL-Adj)
San Diego, CA
$57,341 vs $56,773
2

Detailed Comparison

MetricSan Diego, CASan Francisco, CADiff
Median Annual Salary$104,000$126,000-$22,000
25th Percentile$80,080$97,020-$16,940
75th Percentile$133,120$161,280-$28,160
90th Percentile$166,400$201,600-$35,200
Cost of Living Index152186-34
State Income Tax9.3%9.3%
COL-Adjusted Median$68,421$67,742+$679
Est. Annual Take-Home$87,159$105,597-$18,438
COL-Adj. Take-Home$57,341$56,773+$568
Total Employment19,20041,600-22,400
▲ = Higher value wins for this metric. Diff = San Diego, CA minus San Francisco, CA.

3Summary Analysis

On paper, San Francisco, CA pays $22,000 more (median: $104,000 vs $126,000). However, after adjusting for cost of living (index 152 vs 186), San Diego, CA provides better purchasing power ($68,421 vs $67,742 equivalent). San Francisco, CA has the lower state tax rate (9.3% vs 9.3%).

Data: U.S. Bureau of Labor Statistics OEWS · 2026 · Cost-of-living indices from composite metro area data. Take-home estimates approximate only — consult a tax professional for accurate figures.